The A283 Steyning Road in Shoreham is closed due to an accident.
There is queuing traffic in both directions between the A27 Shoreham bypass junction and the Hensfield Road junction. There were delays of up to 40 minutes.
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A spokesman from Sussex Police said: "The A283 Steyning Road near the old cement works has been closed on Monday morning (January 27) following a collision between a car and a lorry around 7.35am.
"Police, ambulance and fire services are in attendance, but at this stage it would appear that there have been only minor injuries.
"The road remains closed at 8.45am while recovery work takes place and the highways authority has been called to deal with oil on the carriageway."
More to follow