Changes to a busy junction will begin next month and are expected to last until the end of the year.
Brighton and Hove City Council has announced that safety improvements to the busy Vogue gyratory system are being planned to start in July.
Council officials say the work is expected to last up to five months at the junction which is used by 60,000 pedestrians, cyclists, bus passengers and motorists a day.
The council’s transport team said it intended to take advantage of lighter traffic during summer holidays to start the improvements when there will be fewer students and commuters.
The £750,000 improvement scheme follows a public consultation in April 2012 which revealed 65% of residents consulted supported the idea of making the junction less hazardous.
As part of the changes, traffic signals will be replaced and a two metre wide cycle lane going north will run inside a “floating” bus stop which will accommodate bendy buses for the first time. The junction will be resurfaced and there will also be improvements to pavements and crossing points.
Priority traffic lights for cyclists will give a three-second head-start to help keep them clear of vehicles. It is anticipated the biggest disruption will be in mid August with the temporary closure of access to and from Upper Lewes Road from the gyratory.
The council is writing to hundreds of homes and business in the area detailing the work plans with businesses being specifically consulted on how the council can maintain access to their premises.
Lead councillor for transport Ian Davey said: “We apologise in advance for any disruption during these important works.
“But improvements to this junction are long overdue and it’s vital that we do what we can to stop collisions, prevent people getting injured, speed bus journeys and make it more pleasant and safe for cyclists and pedestrians.”