Rail services have been delayed or cancelled because of problems including a shortage of workers.
Passengers on Southern Railway services between Brighton and Southampton were warned to expect cancellations for the rest of the week because of a lack of available conductors.
The company, which urged people to check before they travel, said sickness absence at some depots is double the usual number.
Chief operating officer Dyan Crowther said: "We are extremely disappointed and frustrated that, due to an unusually high level of sickness among some of our conductors and some others not working their normal rest days, we are unable to run the full service between Southampton and Brighton.
"We know this will come as an added blow after last week's conductors' strike by members of the RMT union.
"We've done our best for passengers by making these changes to a route where there are alternative services, but we know it is going to be difficult.
"When our plans to evolve the role of conductor are implemented, this type of cancellation and disruption to passengers will be vastly reduced."
A broken rail at Redhill in Surrey affected Gatwick Express, Southern and Thameslink services.
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