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Clarke back as Reds make four changes
Clarke came off the bench to score the equaliser and set up Nicky Ajose's winner as the Reds shocked Bolton 2-1 in the Capital One Cup on Tuesday.
His reward was a place in the starting line-up as the Reds looked to make it three league wins from four games following promotion.
Skipper Gary Alexander, David Hunt and Josh Simpson also returned to the starting line-up with Mark Connolly, Shaun Cooper and Jonathan Forte dropping to the bench and Sergio Torres missing out through injury.
Deadline day signing Mike Jones, from Sheffield Wednesday, also had to be content with a place among the substitutes along.
There was also a first involvement for former Swansea City left-back Joe Walsh, signed last week.
Crawley: P.Jones; Hunt, Davis, McFadzean, Sadler; Adams, Simpson, Akpan, Clarke; Alexander, Ajose. Subs: Connolly, Forte, Walsh, Bulman, Cooper, M.Jones, Kuipers.
Leyton Orient: Allsop; McSweeney, Chorley, Clarke, Sawyer; Odubajo, Griffith, Rowlands, Cook; Cox; Symes. Subs: Baudry, Lisbie, Smith, Laird, Grainger, Brunt, Mooney.