Will Buckley and Will Hoskins also come into the team as the Seagulls look to build on Saturday’s 1-0 win at home to Hull when Vicente came off the bench to score the only goal.
It is only the former Spain international’s second league start of an injury-hit campaign after playing in the reverse fixture at Blackburn three weeks ago.
Craig Mackail-Smith, Andrea Orlandi and David drop to the bench.
Blackburn hand a full debut to QPR loan signing DJ Campbell alongside the prolific Jordan Rhodes.
Albion: Kuszczak; Bruno, El-Abd, Upson, Bridge; Bridcutt, Vicente, Hammond; Buckley; Ulloa, Hoskins. Sub: Calderon, Dicker, Orlandi, David, LuaLua, Mackail-Smith, Ankergren.
Blackburn: Kean; Orr, Dann, Hanley, Martin Olsson; Kazim-Richards, Lowe, Murphy, Markus Olsson; Rhodes, Campbell. Subs: Givet, Pedersen, Williamson, Nuno Gomes, Morris, Goodwillie, Usai.