The University of Brighton is ranked 13th in the Southeast in The Times and The Sunday Times Good University Guide 2026.
It also occupies joint 90th place in the national rankings.
The University of Oxford is the top university in the Southeast 2026 and Medical School of the Year 2026.
It also finished in joint fourth in the national rankings, making it the highest-ranked university in the Southeast.
The University of Southampton is the second highest-ranked university in the Southeast, finishing in 17th in the national table.
The University of Surrey is third in the Southeast, while the University of Reading and the University of Sussex complete the top five.
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At the bottom of the Southeast rankings are the University of Buckingham, the University for the Creative Arts, and Buckinghamshire New University.
Helen Davies, editor of The Times and The Sunday Times Good University Guide, said: "In a very competitive top ten Durham has climbed two places in a year, which is a significant achievement.
"In doing so it has outdone both Oxford and Cambridge, helping to push them out of the top three in our league table for the first time in the Good University Guide’s history."
She continued: "Its stellar academic performance was boosted this year by improvements in teaching quality, and student experience.
"Durham also won University of the Year in the North and Northeast 2026 and runner-up University of the Year for Graduate Prospects 2026.
"Competition to get a place at our top-ranked institutions continues to grow, leaving some lower-tariff universities with recruitment challenges.
"It is exciting to see universities across the UK working to deliver extraordinary medical and technical breakthroughs, lead economic regeneration and inspire."
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