Grace stars John Simm and Richie Campbell are filming in the city centre.
Crews were seen at Marlborough House in Old Steine, Brighton, today, June 11.
At the scene were fire engines and police tape, with smoke billowing out of the building during takes.
ITV confirmed that the seventh series of hit crime drama Grace, based on the novels of Brighton-born Peter James, had been commissioned in April.
Grace filming in Old Steine, Brighton (Image: The Argus)
Grace, which is set in Brighton and Hove, returned to TV screens in March for its sixth season.
In July, filming for series six took place at a property in Cowley Drive, Brighton.
Filming also took place in August, when Woodingdean residents were told that a location would be transformed into a money exchange office for the filming of a bank robbery scene.
John Simm and Richie Campbell (Image: The Argus)
A letter told residents not to be alarmed if they see police, masked men or a getaway car.
Crews were also spotted at Sovereign House in Church Street, Brighton, where a 'Saxonhurst Building Society' sign appeared on the front of the building, with filming equipment and lorries occupying Tichborne Street.
Executive producer Phil Hunter said: “Straight off the back of the success of series six on ITV and ITVX, I’m thrilled that we are back for a seventh series.
John Simm and Richie Campbell (Image: The Argus)
"Following Cleo’s kidnap, we pick up Grace and his team under more pressure than ever for what promises to be another propulsive and explosive run of episodes.
"I can’t wait to see our brilliant cast and crew rise to the challenge of shooting another four stories based on Peter James’ iconic characters.”
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Louise Ogunnaike, who oversees the drama for ITV, said: “Grace has become a cornerstone of the ITV schedule and the audience’s appetite for Roy Grace’s world only seems to grow with every season.
John Simm and Richie Campbell (Image: The Argus)
"Reaching a seventh series is a testament to the incredible partnership between Peter James’ world, the brilliant scripts from the writing team, and the dedicated cast and production team who bring this series to life.
"We are delighted to be returning to Brighton for a seventh season and to bring four more gripping investigations to our screens.”