Mason Greenwood is back in the Manchester United team at the Amex.
The young England striker, who impressed here late last season, is one of three changes to the XI which lost to Crystal Palace last week.
United boss Ole Gunnar Solskjaer has named what is thought to be his strongest line-up.
How Albion line-up against Manchester United
That sees Aaron Wan-Bissaka and Nemanja Matic replace Timothy Fosu-Mensah and Scott McTominay while Dan James makes way for Greenwood.
Manchester United: De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; Pogba, Matic; Greenwood, Fernandes, Rashford; Martial. Subs: Henderson, Bailly, Lingard, Fred, Fosu-Mensah, van de Beek, McTominay.
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