Pascal Gross is back in the starting line-up for Albion.
The German midfielder replaces injured Enock Mwepu in the XI to face Manchester United.
Danny Welbeck leads the attack against his old club.
Cristiano Ronaldo and Juan Mata are among the starters for United.
They name the XI which beat Brentford on Monday while Harry Maguire is on the bench after a knee injury.
Albion: Sanchez; Veltman, Dunk, Cucurella; March, Caicedo, Bissouma, Gross, Mac Allister, Trossard; Welbeck. Subs: Steele, Duffy, Offiah, Lamptey, Webster, Lallana, Alzate, Maupay, Ferguson.
Manchester United: De Gea; Telles, Varane, Lindelof, Dalot; Matic, McTominay, Mata, Fernandes; Elanga, Ronaldo. Subs: Henderson, Wan-Bissaka, Maguire, Fernandez, Jones, Fred, Lingard, Cavani, Garnacho.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here