Albion have handed Alan Navarro a first start since the opening week of the season.
The midfielder, who has spent the winter battling injury, comes into the side as one of four changes as the Seagulls visit Colchester.
Lewis Dunk gets a chance to impress in defence, Craig Noone starts on the wing and Chris Wood replaces the injured Glenn Murray.
Colchester lost star striker Steven Gillespie for the season when he fractured his arm in the draw at Brentford on Good Friday.
Top scorer David Mooney, with 13 goals this season, leads the attack and Ian Henderson could play just behind him.
Their side includes former Albion loanee Matt Heath in central defence.
Ccolchester: Williams; Wilson, Heath, Smith, Powell; James, Izzet, O'Toole, Vincent; Henderson, Mooney. Subs: Clarke, Cousins, Bond, Odejayi, Wordsworth, Coker, White.
Albion: Ankergren; Calderon, Elphick, Dunk, Painter; Bennett, Dicker, Navarro, Noone; Wood, Barnes. Subs: Brezovan, El-Abd, Sparrow, Hart, Sandaza, Kishishev, Bridcutt.
Ref: KP Stroud
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