The A24 southbound is now open again after a four-vehicle accident at the Hop Oast Park & Ride Roundabout.
The incident was between the B2237 Worthing Road and A272 (Buckbarn Crossroads).
The road was closed to clean up spilt oil and recover any wreckage, after the accident at about 3.30pm.
Sussex Police said there were only minor injuries and vehicles were all recovered.
The road was open by 6.30pm.
Traffic can divert through the centre of Southwater.
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