Fire crews are at the scene of a blaze in a ground floor flat.
The emergency services were called by a member of the public just after 6.30pm to a fire in Grinstead Mount, Nuthurst Place, Whitehawk, Brighton.
Two adults were taken to hospital suffering smoke inhalation and two children were treated by paramedics at the scene.
The cause of the fire is being investigated by East Sussex Fire and Rescue and Sussex Police.
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