Lewes can secure National League division two survival if they win at home to bottom side Blueharts and Peterborough Town lose away to Hounslow and Ealing.
Skipper Will Champness said: "We are hopeful we can do our bit and Hounslow can do the rest."
Lewes are without Ryan Ibbotson, so 2nd XI captain Liam Russell is added to the squad.
Meanwhile, East Grinstead have a double bill of action as they entertain Formby in a rearranged game tomorrow before playing host to Bath Buccaneers on Sunday.
Nine-goal forward Steve Edmonds has been ruled out for the season with a broken finger. Matt McNeill misses both games this weekend with an ankle problem while Richard Payne is unavailable.
John Sullivan returns from injury while second team top scorer Alex Pizzey is added to the squad. David Litchfield, who is also back from a knee problem, and Phil Coote will be added to the squad on Sunday.
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