Albion defender Inigo Calderon is on standby for his third home start of the season.
He will replace Bruno at right-back for Nottingham Forest’s visit to The Amex on Saturday if his fellow Spaniard is not 100% fit.
Bruno has been struggling with rib and calf problems in recent matches.
The former Valencia star went off at Charlton on Saturday with 15 minutes left, as soon as Kazenga LuaLua struck the Seagulls’ second equaliser.
Manager Gus Poyet said: “Bruno had tendonitis in his Achilles. He’s had too many problems in the last few weeks, so he hasn’t been training properly and when you are going to The Valley if you are not 100% it’s going to be difficult for you. It was getting worse so we didn’t want to risk it. We’ll see. I hope it’s a little bit of tiredness and nothing more.”
Calderon took over in the closing stages and deputised for the injured Bruno earlier in the season in home games against Birmingham and Ipswich.
Poyet will not hesitate in turning to the versatile 30-year-old if there are doubts about Bruno’s fitness.
The Uruguayan said: “Sometimes you are a little bit unfair because he (Calderon) performs and you don’t play him. I think we need to make sure the players who are going to play this week are 100% fit at the back. If not Calde has to play.”
Forest are immediately below eighth-placed Albion on goal difference.